Computational Framework Research Articles

Machine Learning Reveals Impacts of Smoking on Gene Profiles of Different Cell Types in Lung

Smoking significantly elevates the risk of lung diseases such as chronic obstructive pulmonary disease (COPD) and lung cancer. This risk is attributed to the harmful chemicals in tobacco smoke that damage lung tissue and impair lung function. Current research on the impact of smoking on gene expression in specific lung cells is limited. This study addresses this gap by analyzing gene expression profiles at the single-cell level from 43,539 lung endothelial cells, 234,349 lung epithelial cells, 189,843 lung immune cells, and 16,031 lung stromal cells using advanced machine learning techniques. The data, categorized by different lung cell types, were classified into three smoking states: active smoker, former smoker, and never smoker. Each cell sample encompassed 28,024 feature genes. Employing an incremental feature selection method within a computational framework, several specific genes have been identified as potential markers of smoking status in different lung cell types. These include B2M, EEF1A1, and TPT1 in lung endothelial cells; FTL and MT-ATP8 in lung epithelial cells; HLA-B and HLA-C in lung immune cells; and HSP90B1 and LCN2 in lung stroma cells. Additionally, this study developed quantitative rules for representing the gene expression patterns related to smoking. This research highlights the potential of machine learning in oncology, enhancing our molecular understanding of smoking’s harm and laying the groundwork for future mechanism-based studies.

Comparing Coupled Multiphysics Simulations of Pump-Driven Transients for a Pressurized Heavy Water Reactor

Comparison of results for global responses predicted by different multiphysics simulations of benchmark problems may fail to reveal potentially significant local modeling issues. An examination of code interactions in coupled simulations can provide more information, which may help identify potential modeling issues that went unnoticed during verification (and validation) of the individual codes, or may call into question approximations otherwise deemed reasonable at the individual code level. We illustrate this challenge for the case of coupled neutronics/thermal-hydraulic transient simulations using one of the problems and contributed results documented in International Atomic Energy Agency TECDOC-1994. This recently published report documents the specifications of four numerical multiphysics pressurized heavy water reactor (PHWR) transient challenge problems and the results contributed by 10 participants. Our work is based on the pump rundown problem, where TECDOC-1994 suggests that differences in modeling and methods employed in thermal-hydraulics may be the dominant factor in the observed differences. We performed a more detailed assessment with two different multiphysics coupled computational frameworks using NESTLE-C/ARIANT and PUMA/RELAP-5. We also studied a pump seizure transient, a more challenging variant of the pump rundown transient. Several aspects were investigated: comparisons of standalone results, sensitivity to gap modeling, selection of boundary conditions at the pressurizer, and an examination of correlations used in ARIANT and RELAP-5. Our assessment goes beyond the results for global parameters and dives into details of predictions at the channel level. This paper briefly describes the PHWR pump rundown transient problem and a pump seizure variant, the computational methods employed, and the areas investigated, and discusses some selected results.

Accelerate Microstructure Evolution Simulation Using Graph Neural Networks with Adaptive Spatiotemporal Resolution

Abstract Surrogate models driven by sizeable datasets and scientific machine-learning methods have emerged as an attractive microstructure simulation tool with the potential to deliver predictive microstructure evolution dynamics with huge savings in computational costs. Taking 2D and 3D grain growth simulations as an example, we present a completely overhauled computational framework based on graph neural networks with not only excellent agreement to both the ground truth phase-field methods and theoretical predictions, but enhanced accuracy and efficiency compared to previous works based on convolutional neural networks. These improvements can be attributed to the graph representation, both improved predictive power and a more flexible data structure amenable to adaptive mesh refinement. As the simulated microstructures coarsen, our method can adaptively adopt remeshed grids and larger timesteps to achieve further speedup.
 The data-to-model pipeline with training procedures together with the source codes are provided.

A Computational Framework for Precise Aerial Agricultural Spray Delivery Processes

A Computational Framework for Precise Aerial Agricultural Spray Delivery Processes

Adaptive backstepping controller based on a novel framework for dynamic solution of an ankle rehabilitation spherical parallel robot

Abstract This research offers an adaptive model-based methodology for autonomous control of 3-RRR spherical parallel manipulator (RSPM) based on a novel modeling framework. RSPM is an overconstrained parallel mechanism that has a variety of applications in medical procedures such as ankle rehabilitation because of its precision and accuracy. However, obtaining a complete explicit dynamic model of these mechanisms for tracking purposes has been a problematic challenge due to their inherent singularities, coupling effects of the limbs, and redundant constraints imposed by the intermediate joints. This paper presents a novel algorithm to obtain the analytical kinematic solutions of RSPMs based on the closed-loop vector method, which includes constraint analysis. By incorporating constrained kinematics into the dynamic model, a comprehensive explicit dynamic solution of the non-overconstrained version 3-RCC of RSPM is developed in task space, based on screw theory and the linear homogeneous property of algebraic equations on the manipulator twist. Based on the proposed computational framework, a robust self-tuning backstepping control (STBC) strategy is applied to the robot to overcome the effect of external disturbances and time-varying uncertainties. Furthermore, an observer-based compensation (OBC) method is presented for dealing with the nonlinear hysteresis loops of the ankle during trajectory tracking purposes. The closed-loop stability of the whole system including STBC and OBC is theoretically performed by Lyapunov methods. The proposed methodologies are validated by realistic co-simulations in different scenarios. For instant, in the presence of external disturbances, the maximum tracking error norm of STBC is 37.5% less than the sliding mode approach.

A novel framework for three-dimensional electrical impedance tomography reconstruction of maize ear via feature reconfiguration and residual networks

Electrical impedance tomography (EIT) provides an indirect measure of the physiological state and growth of the maize ear by reconstructing the distribution of electrical impedance. However, the two-dimensional (2D) EIT within the electrode plane finds it challenging to comprehensively represent the spatial distribution of conductivity of the intact maize ear, including the husk, kernels, and cob. Therefore, an effective method for 3D conductivity reconstruction is necessary. In practical applications, fluctuations in the contact impedance of the maize ear occur, particularly with the increase in the number of grids and computational workload during the reconstruction of 3D spatial conductivity. These fluctuations may accentuate the ill-conditioning and nonlinearity of the EIT. To address these challenges, we introduce RFNetEIT, a novel computational framework specifically tailored for the absolute imaging of the three-dimensional electrical impedance of maize ear. This strategy transforms the reconstruction of 3D electrical conductivity into a regression process. Initially, a feature map is extracted from measured boundary voltage via a data reconstruction module, thereby enhancing the correlation among different dimensions. Subsequently, a nonlinear mapping model of the 3D spatial distribution of the boundary voltage and conductivity is established, utilizing the residual network. The performance of the proposed framework is assessed through numerical simulation experiments, acrylic model experiments, and maize ear experiments. Our experimental results indicate that our method yields superior reconstruction performance in terms of root-mean-square error (RMSE), correlation coefficient (CC), structural similarity index (SSIM), and inverse problem-solving time (IPST). Furthermore, the reconstruction experiments on maize ears demonstrate that the method can effectively reconstruct the 3D conductivity distribution.

Nonlinear elasticity with the Shifted Boundary Method

We propose a new unfitted/immersed computational framework for nonlinear solid mechanics, which bypasses the complexities associated with the generation of CAD representations and subsequent body-fitted meshing. This approach allows to speed up the cycle of design and analysis in complex geometry and requires relatively simple computer graphics representations of the surface geometries to be simulated, such as the Standard Tessellation Language (STL format). Complex data structures and integration on cut elements are avoided by means of an approximate boundary representation and a modification (shifting) of the boundary conditions to maintain optimal accuracy. An extensive set of computational experiments in two and three dimensions is included.

A modular computational framework for the dynamic analyses of cable-driven parallel robots with different types of actuation including the effects of inertia, elasticity and damping of cables

Abstract Dynamic simulations of the cable-driven parallel robots (CDPRs) with cable models closer to reality can predict the motions of moving platforms more accurately than those with idealisations. Hence, the present work proposes an efficient and modular computational framework for this purpose. The primary focus is on the developments required in the context of CDPRs actuated by moving the exit points of cables while the lengths are held constant. Subsequently, the framework is extended to those cases where simultaneous changes in the lengths of cables are employed. Also, the effects due to the inertia, stiffness and damping properties of the cables undergoing 3D motions are included in their dynamic models. The efficient recursive forward dynamics algorithms from the prior works are utilised to minimise the computational effort. Finally, the efficacy of the proposed framework and the need for such an inclusive dynamic model are illustrated by applying it to different application scenarios using the spatial $4$ - $4$ CDPR as an example.

A novel train–bridge interaction computational framework based on a meshless box girder model

In traditional train–bridge coupled system (TBCS), simply supported box girder bridges are often modeled using Euler beam elements, neglecting their spatial structure. This simplification may yield inaccurate results, impacting the running safety analysis of high-speed railway. To address this issue, a novel train–bridge interaction computational framework based on first-order shear deformation theory (FSDT) and radial point interpolation method (RPIM) for the box girder bridge model is proposed. In this model, the displacement fields of top, bottom, and web plates are represented using FSDT and numerically discretized by RPIM. The traditional TBCS is upgraded by replacing the Euler beam model with the novel model. This is the first time that the framework has been applied to TBCS field. Several numerical examples are presented to highlight the accuracy of this novel model, and illustrate the differences, and advantages of it over the traditional model. The results indicate that the proposed model closely matches the accuracy of the solid element (C3D20) model; it can provide a comprehensive bridge response compared to traditional TBCS, and the latter may underestimate the dynamic response of the structure. The proposed model holds significant potential for the simulation of box structures and widespread application in the field of TBCS.

Blockchain-Enhanced Sensor-as-a-Service (SEaaS) in IoT: Leveraging Blockchain for Efficient and Secure Sensing Data Transactions

As the Internet of Things (IoT) continues to revolutionize value-added services, its conventional architecture exhibits persistent scalability and security vulnerabilities, jeopardizing the trustworthiness of IoT-based services. These architectural limitations hinder the IoT’s Sensor-as-a-Service (SEaaS) model, which enables the commercial transmission of sensed data through cloud platforms. This study proposes an innovative computational framework that integrates decentralized blockchain technology into the IoT architectural design, specifically enhancing SEaaS efficiency. This research contributes to an optimized IoT architecture with decentralized blockchain operations and simplified public key encryption. Furthermore, this study introduces an advanced SEaaS model featuring innovative trading operations for sensed data among diverse stakeholders. At its core, this model presents a unique blockchain-based data-sharing mechanism that manages multiple aspects, from enrollment to validation. Evaluations conducted in a standard Python environment indicate that the proposed SEaaS model outperforms existing blockchain-based data-sharing models, demonstrating approximately 40% less energy consumption, 18% increased throughput, 16% reduced latency, and a 25% reduction in algorithm processing time. Ultimately, integrating a lightweight authentication mechanism using simplified public key cryptography within the blockchain establishes the model’s potential for efficient and secure data-sharing in IoT.

Neural‐Optic Co‐Designed Polarization‐Multiplexed Metalens for Compact Computational Spectral Imaging

AbstractIn the expanding fields of mobile technology and augmented reality, there is a growing demand for compact, high‐fidelity spectral imaging systems. Traditional spectral imaging techniques face limitations due to their size and complexity. Diffractive optical elements (DOEs), although helpful in reducing size, primarily modulate the phase of light. Here, an end‐to‐end computational spectral imaging framework based on polarization‐multiplexed metalens is introduced. A distinguishing feature of this approach lies in its capacity to simultaneously modulate orthogonal polarization channels. When harnessed in conjunction with a neural network, it facilitates the attainment of high‐fidelity spectral reconstruction. Importantly, the framework is intrinsically fully differentiable, a feature that permits the joint optimization of both the metalens structure and the parameters governing the neural network. The experimental results presented herein validate the exceptional spatial‐spectral reconstruction performance, underscoring the efficacy of this system in practical, real‐world scenarios. This innovative approach transcends the traditional boundaries separating hardware and software in the realm of computational imaging and holds the promise of substantially propelling the miniaturization of spectral imaging systems.

Design Optimization of Lattice Structures Under Impact Loading for Additive Manufacturing

Abstract Additive manufacturing (AM) has enabled the production of intricate lattice structures with excellent performance and minimal mass. Design approaches that consider static loading, including lattice-based topology optimization (TO), have been well-researched recently. However, to date, there appears to be no widely accepted method of optimizing lattice structures for high-strain rate loading, especially when the design for additive manufacturing (DFAM) principles are considered. This study proposes a computational framework for the design of lattice structures under specified impact loading. To manage dimensionality while achieving sufficient generality, a heuristic design space is developed that relies on traditional TO to govern the design's macrostructure and standard dimensioning to govern its mesostructure. DFAM principles are then incorporated into a Bayesian optimization scheme wrapped around traditional TO to achieve manufacturable designs that absorb high-impact loading. Because this approach does not require analytical gradient information, the framework can be used to optimize directly on complex objectives, such as injury metrics calculated from the acceleration curve. A series of case studies is formulated around a mass-performance tradeoff and involves individual unit cell design as well as full-part design. The proposed design parameterization is found to enable sufficient flexibility to achieve consistently good performance regardless of AM build orientation.

Energy-constrained production optimization for the in-situ conversion process of oil shale based on deep learning algorithms

The in-situ conversion process (ICP) involves complicated thermal-reactive-compositional flow processes where the production parameters are closely interdependent. Therefore, manual optimization of the production parameters of ICP through numerical simulation is arduous and time-consuming. This paper introduces a computational framework that integrates deep learning techniques and particle swarm optimization (PSO) to automatically optimize the values of production parameters of ICP, and thus locating the highest energy efficiency and the optimum energy usage. This approach utilizes a 3D CNN model to predict key metrics. The prediction process considers the detailed 3D heterogeneity of oil shale, resulting in remarkably high prediction accuracy, as evidenced by determination coefficients (R2) above 0.99. Subsequently, the trained CNN model is integrated to the PSO algorithm to automatically fine-tune the production parameters to optimize the energy efficiency of ICP.The optimization results yield three significant findings. First, as the energy consumption limit increases, the optimal number of heaters, well spacing, and heating temperature exhibit an upward trend, but stabilized beyond the threshold of 7 × 105 kWh. Secondly, the optimal input energy (7 × 105 kWh) is found for the given ICP model. Lastly, the analysis reveals that variations in initial reservoir pressure or bottomhole pressure have limited impact on cumulative oil production and energy usage.

Model-based closed-loop control of thalamic deep brain stimulation

Introduction: Closed-loop control of deep brain stimulation (DBS) is beneficial for effective and automatic treatment of various neurological disorders like Parkinson’s disease (PD) and essential tremor (ET). Manual (open-loop) DBS programming solely based on clinical observations relies on neurologists’ expertise and patients’ experience. Continuous stimulation in open-loop DBS may decrease battery life and cause side effects. On the contrary, a closed-loop DBS system uses a feedback biomarker/signal to track worsening (or improving) of patients’ symptoms and offers several advantages compared to the open-loop DBS system. Existing closed-loop DBS control systems do not incorporate physiological mechanisms underlying DBS or symptoms, e.g., how DBS modulates dynamics of synaptic plasticity.Methods: In this work, we propose a computational framework for development of a model-based DBS controller where a neural model can describe the relationship between DBS and neural activity and a polynomial-based approximation can estimate the relationship between neural and behavioral activities. A controller is used in our model in a quasi-real-time manner to find DBS patterns that significantly reduce the worsening of symptoms. By using the proposed computational framework, these DBS patterns can be tested clinically by predicting the effect of DBS before delivering it to the patient. We applied this framework to the problem of finding optimal DBS frequencies for essential tremor given electromyography (EMG) recordings solely. Building on our recent network model of ventral intermediate nuclei (Vim), the main surgical target of the tremor, in response to DBS, we developed neural model simulation in which physiological mechanisms underlying Vim–DBS are linked to symptomatic changes in EMG signals. By using a proportional–integral–derivative (PID) controller, we showed that a closed-loop system can track EMG signals and adjust the stimulation frequency of Vim–DBS so that the power of EMG reaches a desired control target.Results and discussion: We demonstrated that the model-based DBS frequency aligns well with that used in clinical studies. Our model-based closed-loop system is adaptable to different control targets and can potentially be used for different diseases and personalized systems.

Computational framework for identifying and evaluating mutagenic and xenoestrogenic potential of food additives

Food additives are chemicals incorporated in food to enhance its flavor, color and prevent spoilage. Some of these are associated with substantial health hazards, including developmental disorders, increase cancer risk, and hormone disruption. Hence, this study aimed to comprehend the in-silico toxicology framework for evaluating mutagenic and xenoestrogenic potential of food additives and their association with breast cancer. A total of 2885 food additives were screened for toxicity based on Threshold of Toxicological Concern (TTC), mutagenicity endpoint prediction, and mutagenic structural alerts/toxicophores identification. Ten food additives were identified as having mutagenic potential based on toxicity screening. Furthermore, Protein-Protein Interaction (PPI) analysis identified ESR1, as a key hub gene in breast cancer. KEGG pathway analysis verified that ESR1 plays a significant role in breast cancer pathogenesis. Additionally, competitive interaction studies of the predicted potential mutagenic food additives with the estrogen receptor-α were evaluated at agonist and antagonist binding sites. Indole, Dichloromethane, Trichloroethylene, Quinoline, 6-methyl quinoline, Ethyl nitrite, and 4-methyl quinoline could act as agonists, and Paraldehyde, Azodicarbonamide, and 2-acetylfuranmay as antagonists. The systematic risk assessment framework reported in this study enables the exploration of mutagenic and xenoestrogenic potential associated with food additives for hazard identification and management.

Metacell-based differential expression analysis identifies cell type specific temporal gene response programs in COVID-19 patient PBMCs

By profiling gene expression in individual cells, single-cell RNA-sequencing (scRNA-seq) can resolve cellular heterogeneity and cell-type gene expression dynamics. Its application to time-series samples can identify temporal gene programs active in different cell types, for example, immune cells’ responses to viral infection. However, current scRNA-seq analysis has limitations. One is the low number of genes detected per cell. The second is insufficient replicates (often 1-2) due to high experimental cost. The third lies in the data analysis—treating individual cells as independent measurements leads to inflated statistics. To address these, we explore a new computational framework, specifically whether “metacells” constructed to maintain cellular heterogeneity within individual cell types (or clusters) can be used as “replicates” for increasing statistical rigor. Toward this, we applied SEACells to a time-series scRNA-seq dataset from peripheral blood mononuclear cells (PBMCs) after SARS-CoV-2 infection to construct metacells, and used them in maSigPro for quadratic regression to find significantly differentially expressed genes (DEGs) over time, followed by clustering expression velocity trends. We showed that such metacells retained greater expression variances and produced more biologically meaningful DEGs compared to either metacells generated randomly or from simple pseudobulk methods. More specifically, this approach correctly identified the known ISG15 interferon response program in almost all PBMC cell types and many DEGs enriched in the previously defined SARS-CoV-2 infection response pathway. It also uncovered additional and more cell type-specific temporal gene expression programs. Overall, our results demonstrate that the metacell-pseudoreplicate strategy could potentially overcome the limitation of 1-2 replicates.

Abstract LB242: Prediction of patient response to neoadjuvant chemotherapy in breast cancer from their deconvolved tumor microenvironment transcriptome

Abstract Introduction: The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays critical roles in tumor development and clinical outcome. While the multifarious cellular interactions within the TME have been extensively studied with a significant emphasis on immunotherapy, understanding its role in chemotherapy outcome remains less explored. To this end, we present a novel generic computational framework named DECODEM (DEcoupling Cell-type-specific Outcomes using DEconvolution and Machine learning). DECODEM facilitates the exploration of the association of cell-type-specific gene expression profiles with the effectiveness of neoadjuvant chemotherapy (NAC) in treating breast cancer (BC). This approach holds promise for elucidating the nuanced ways in which the TME can modulate therapeutic efficacy, potentially paving the way for more personalized and effective cancer treatments. Methods: DECODEM employs cellular deconvolution of bulk transcriptomics to extract cell-type-specific gene expression profiles within the TME, and subsequently harnesses machine learning to construct cell-type-specific predictors of clinical outcomes. Utilizing DECODEM, we analyzed three publicly available cohorts of HER2-negative BC patients who received NAC. We assessed the predictive capabilities of the individual cell types as well as their collective influence, benchmarking against a state-of-the-art predictor that employs both clinical and transcriptomic features. We corroborated our findings in a single-cell (SC) transcriptomics cohort of patients with triple negative breast cancer (TNBC) undergoing chemotherapy. Further, we expanded DECODEM to DECODEMi, which accounts for cell-cell interactions (CCIs) among the predominant cell types, offering potential insights into the mechanistic processes governing clinical responses. Results: Our analysis indicated that the heterogeneous composition of the TME is crucial for chemotherapy response prediction in HER2-negative BC, beyond the influence of malignant cells alone. The key insights from our study are as follows:1. Gene expression of immune cells (myeloid, plasmablasts, B-cells) and stromal cells (endothelial, normal epithelial, cancer-associated fibroblasts) displayed comparable-to-superior predictive powers over both bulk expression and the state-of-the-art predictor.2. The predictive accuracy is further augmented by multi-cell-type ensembles, with a triad ensemble comprising endothelial, myeloid, and plasmablast cells achieving the highest predictive accuracy across multiple cohorts.3. DECODEMi can effectively capture the regulatory impact of CCIs (validated in a SC dataset sourced from the SC-TNBC cohort) and has identified novel CCIs likely to influence chemotherapy response in HER2-negative BC. Conclusion: We provide an unprecedented computational methodology to quantitatively assess the cell-type-specific influences of the TME on clinical outcome. Our analysis offers insights into the complex interactions among TME cells and their correlation with chemotherapy efficacy in HER2-negative BC, thereby enriching the knowledge base of BC treatment effectiveness. Citation Format: Saugato Rahman Dhruba, Sahil Sahni, Binbin Wang, Di Wu, Yael Schmidt, Eldad Shulman, Sanju Sinha, Stephen-John Sammut, Carlos Caldas, Kun Wang, Eytan Ruppin. Prediction of patient response to neoadjuvant chemotherapy in breast cancer from their deconvolved tumor microenvironment transcriptome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB242.

A network of transcriptomic signatures identifies novel comorbidity mechanisms between schizophrenia and somatic disorders

The clinical burden of mental illness, in particular schizophrenia and bipolar disorder, are driven by frequent chronic courses and increased mortality, as well as the risk for comorbid conditions such as cardiovascular disease and type 2 diabetes. Evidence suggests an overlap of molecular pathways between psychotic disorders and somatic comorbidities. In this study, we developed a computational framework to perform comorbidity modeling via an improved integrative unsupervised machine learning approach based on multi-rank non-negative matrix factorization (mrNMF). Using this procedure, we extracted molecular signatures potentially explaining shared comorbidity mechanisms. For this, 27 case–control microarray transcriptomic datasets across multiple tissues were collected, covering three main categories of conditions including psychotic disorders, cardiovascular diseases and type II diabetes. We addressed the limitation of normal NMF for parameter selection by introducing multi-rank ensembled NMF to identify signatures under various hierarchical levels simultaneously. Analysis of comorbidity signature pairs was performed to identify several potential mechanisms involving activation of inflammatory response auxiliarily interconnecting angiogenesis, oxidative response and GABAergic neuro-action. Overall, we proposed a general cross-cohorts computing workflow for investigating the comorbid pattern across multiple symptoms, applied it to the real-data comorbidity study on schizophrenia, and further discussed the potential for future application of the approach.

Enhancing Transshipment Decision-making in Transportation Companies through Computational Intelligence: A Bayesian Game Model with Data-Driven Simulations at Guangzhou Port

The challenge of port congestion significantly impedes the efficiency of global trade flows and the economic vitality of hinterland regions. Addressing this issue, our study harnesses computational intelligence to construct a sophisticated Bayesian game model between the government and multiple transportation companies, where the transshipment costs, considered as private information to the companies, play a pivotal role. This research integrates data analytics and machine learning techniques to analyze the strategic decision-making processes of transportation companies, which decide on transshipment based on a critical cost threshold influenced by government subsidies and a probabilistic assessment of transshipment costs. Utilizing backward induction, the study outlines how the government can leverage computational models to devise an optimal subsidy strategy for transshipment, taking into account the anticipated responses of the transportation companies. The Bayesian Nash equilibrium identified through our model suggests that companies with costs below a predefined threshold are incentivized by government subsidies to opt for transshipment. This conclusion is further validated through evolutionary game theory analysis, enriched by data-driven simulations. Employing real-world data from Guangzhou Port, we conducted extensive computational simulations to quantify the impact of transshipment subsidies. The findings reveal a substantial alleviation in port congestion, with a 33.7% reduction in congestion levels and a 35% decrease in congestion-related costs, alongside a notable 1.9% increase in government revenue. These simulations, powered by advanced computational algorithms and data analytics, not only underscore the effectiveness of informed subsidy strategies in mitigating port congestion but also demonstrate the potential of integrating computational approaches in logistical and transportation decision-making. This study contributes a novel computational framework to the logistics and transportation literature, offering practical insights for policymakers to tackle the enduring problem of port congestion through data-driven strategies.

Destination competitiveness research over the past three decades: a computational literature review using topic modelling

ABSTRACT The aim of this study is to comprehensively review the topics and themes studied in destination competitiveness research and to enrich tourism researchers’ literature review toolbox with the computational literature review technique. A novel computational literature review framework that can be applied to review tourism research domains characterised by an abundance of literature is developed. Enabled by the developed computational literature review framework with topic modelling, this study offers a comprehensive review of 1,130 destination competitiveness studies. The results identified several promising research topics, themes and theoretical perspectives that can be perused in future destination competitiveness studies.